Proteins with complex architecture as potential targets for drug design: a case study of Mycobacterium tuberculosis.

Lengthy harmonica carrying case co-evolution of Homo sapiens and Mycobacterium tuberculosis, the main causative agent of tuberculosis, resulted in a dramatically successful pathogen species that presents considerable challenge for modern medicine.The continuous and ever increasing appearance of multi-drug resistant mycobacteria necessitates the ide

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VHA-19 is essential in Caenorhabditis elegans oocytes for embryogenesis and is involved in trafficking in oocytes.

There is an urgent need beetlejuice makeup kit to develop new drugs against parasitic nematodes, which are a significant burden on human health and agriculture.Information about the function of essential nematode-specific genes provides insight to key nematode-specific processes that could be targeted with drugs.We have characterized the function o

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Can the MerPAS Passive Air Sampler Discriminate Landscape, Seasonal, and Elevation Effects on Atmospheric Mercury? A Feasibility Study in Mississippi, USA

Accurately measuring gaseous elemental mercury (GEM) concentrations in the atmosphere is important to understand its sources, cycling, distribution, and temporal trends.The MerPAS passive air sampler from Tekran Inc.(Toronto, ON, copyright) captures GEM on sulfur-impregnated activated carbon after it passes through a Radeillo diffusive barrier.Beca

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Prevention of H-Aggregates Formation in Cy5 Labeled Macromolecules

H-aggregates of the cyanine dye Cy5 are formed during covalent linkage to the cationic macromolecule Poly(allylamine) (PAH).The nonfluorescent H-aggregates strongly restrict the usage of the dye for analytical purposes and prevent a quantitative determination of the labeled macromolecules.The harmonica carrying case behavior of the H-aggregates has

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